| 產品編號 | bs-0928R |
| 英文名稱 | Rabbit Anti-phospho-heterochromatin protein 1 (pTyr24) antibody |
| 中文名稱 | 磷酸化異染色質蛋白1抗體（果蠅） |
| 別 名 | heterochromatin protein 1 (phospho Tyr24); heterochromatin protein 1 (phospho Y24); Antigen p25; Cbx 5; Cbx5; Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog; HP1A; HP1Hs alpha; HP1Hs-alpha. |
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Specific References (1) | bs-0928R has been referenced in 1 publications.
[IF=3.057] Terzuoli et al. Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation. (2014) PLoS.On. 9:e84358 WB ; Human.
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| 產品類型 | 磷酸化抗體 |
| 研究領域 | 免疫學 染色質和核信號 昆蟲 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Fruit Fly) |
| 產品應用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr24: EE(p-Y)AV |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.
HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required
for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. SWISS: P05205 Gene ID: N/A Database links: GenBank: ACI96782.1 異染色質蛋白1（Heterochromatin protein 1 (HP1)）一般認為是異染色質的維持者，異染色質是轉錄沉默的固縮DNA，常常與中心粒等區(qū)域有關。這種固縮的DNA被認為是轉錄因子無法接近的，但近期的Science上發(fā)表的兩篇報道對這個觀點提出了挑戰(zhàn)。 這個新的研究提出HP1可能是異染色質活性調控的重要因子，在細胞生理活動中具有的重要功能。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
